High prevalence and incidence of human papillomavirus in a cohort of healthy young African female subjects
Identifieur interne : 000391 ( Main/Exploration ); précédent : 000390; suivant : 000392High prevalence and incidence of human papillomavirus in a cohort of healthy young African female subjects
Auteurs : Deborah Watson-Jones [Royaume-Uni, Tanzanie] ; Kathy Baisley [Royaume-Uni] ; Joelle Brown [Royaume-Uni, Tanzanie] ; Bazil Kavishe [Tanzanie] ; Aura Andreasen [Royaume-Uni, Tanzanie] ; John Changalucha [Tanzanie] ; Philippe Mayaud [Royaume-Uni] ; Saidi Kapiga [Royaume-Uni, Tanzanie] ; Balthazar Gumodoka [Tanzanie] ; Richard J. Hayes [Royaume-Uni] ; Silvia De Sanjosé [Espagne]Source :
- Sexually Transmitted Infections [ 1368-4973 ] ; 2013-08.
Abstract
Objectives We measured the prevalence and incidence of human papillomavirus (HPV) infection in young female subjects recruited for a safety and immunogenicity trial of the bivalent HPV-16/18 vaccine in Tanzania. Methods Healthy HIV negative female subjects aged 10–25 years were enrolled and randomised (2:1) to receive HPV-16/18 vaccine or placebo (Al(OH)3 control). At enrolment, if sexually active, genital specimens were collected for HPV DNA, other reproductive tract infections and cervical cytology. Subjects were followed to 12 months when HPV testing was repeated. Results In total 334 participants were enrolled; 221 and 113 in vaccine and control arms, respectively. At enrolment, 74% of 142 sexually active subjects had HPV infection of whom 69% had >1 genotype. Prevalent infections were HPV-45 (16%), HPV-53 (14%), HPV-16 (13%) and HPV-58 (13%). Only age was associated with prevalent HPV infection at enrolment. Among 23 girls who reported age at first sex as 1 year younger than their current age, 15 (65.2%) had HPV infection. Of 187 genotype-specific infections at enrolment, 51 (27%) were present at 12 months. Overall, 67% of 97 sexually active participants with results at enrolment and 12 months had a new HPV genotype at follow-up. Among HPV uninfected female subjects at enrolment, the incidence of any HPV infection was 76 per 100 person-years. Conclusions Among young women in Tanzania, HPV is highly prevalent and acquired soon after sexual debut. Early HPV vaccination is highly recommended in this population.
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DOI: 10.1136/sextrans-2012-050685
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incidence of human papillomavirus in a cohort of healthy young African female subjects</title><author><name sortKey="Watson Jones, Deborah" sort="Watson Jones, Deborah" uniqKey="Watson Jones D" first="Deborah" last="Watson-Jones">Deborah Watson-Jones</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza</wicri:regionArea><wicri:noRegion>Mwanza</wicri:noRegion></affiliation></author><author><name sortKey="Baisley, Kathy" sort="Baisley, Kathy" uniqKey="Baisley K" first="Kathy" last="Baisley">Kathy Baisley</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Brown, Joelle" sort="Brown, Joelle" uniqKey="Brown J" first="Joelle" last="Brown">Joelle Brown</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza</wicri:regionArea><wicri:noRegion>Mwanza</wicri:noRegion></affiliation></author><author><name sortKey="Kavishe, Bazil" sort="Kavishe, Bazil" uniqKey="Kavishe B" first="Bazil" last="Kavishe">Bazil Kavishe</name><affiliation wicri:level="1"><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza</wicri:regionArea><wicri:noRegion>Mwanza</wicri:noRegion></affiliation></author><author><name sortKey="Andreasen, Aura" sort="Andreasen, Aura" uniqKey="Andreasen A" first="Aura" last="Andreasen">Aura Andreasen</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza</wicri:regionArea><wicri:noRegion>Mwanza</wicri:noRegion></affiliation></author><author><name sortKey="Changalucha, John" sort="Changalucha, John" uniqKey="Changalucha J" first="John" last="Changalucha">John Changalucha</name><affiliation wicri:level="1"><country xml:lang="fr">Tanzanie</country><wicri:regionArea>National Institute for Medical Research, Mwanza</wicri:regionArea><wicri:noRegion>Mwanza</wicri:noRegion></affiliation></author><author><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kapiga, Saidi" sort="Kapiga, Saidi" uniqKey="Kapiga S" first="Saidi" last="Kapiga">Saidi Kapiga</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza</wicri:regionArea><wicri:noRegion>Mwanza</wicri:noRegion></affiliation></author><author><name sortKey="Gumodoka, Balthazar" sort="Gumodoka, Balthazar" uniqKey="Gumodoka B" first="Balthazar" last="Gumodoka">Balthazar Gumodoka</name><affiliation wicri:level="1"><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Bugando Medical Centre, Mwanza</wicri:regionArea><wicri:noRegion>Mwanza</wicri:noRegion></affiliation></author><author><name sortKey="Hayes, Richard J" sort="Hayes, Richard J" uniqKey="Hayes R" first="Richard J" last="Hayes">Richard J. Hayes</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Institut Català d'Oncologia, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiologia, y Salud Publica, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Sexually Transmitted Infections</title><title level="j" type="abbrev">Sex Transm Infect</title><idno type="ISSN">1368-4973</idno><idno type="eISSN">1472-3263</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-08">2013-08</date><biblScope unit="volume">89</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="358">358</biblScope></imprint><idno type="ISSN">1368-4973</idno></series><idno type="istex">5FDA8340F9E57854D7D42B00010745736505DE84</idno><idno type="DOI">10.1136/sextrans-2012-050685</idno><idno type="href">sextrans-89-358.pdf</idno><idno type="ArticleID">sextrans-2012-050685</idno><idno type="PMID">23486859</idno><idno type="local">sextrans;89/5/358</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1368-4973</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives We measured the prevalence and incidence of human papillomavirus (HPV) infection in young female subjects recruited for a safety and immunogenicity trial of the bivalent HPV-16/18 vaccine in Tanzania. Methods Healthy HIV negative female subjects aged 10–25 years were enrolled and randomised (2:1) to receive HPV-16/18 vaccine or placebo (Al(OH)3 control). At enrolment, if sexually active, genital specimens were collected for HPV DNA, other reproductive tract infections and cervical cytology. Subjects were followed to 12 months when HPV testing was repeated. Results In total 334 participants were enrolled; 221 and 113 in vaccine and control arms, respectively. At enrolment, 74% of 142 sexually active subjects had HPV infection of whom 69% had >1 genotype. Prevalent infections were HPV-45 (16%), HPV-53 (14%), HPV-16 (13%) and HPV-58 (13%). Only age was associated with prevalent HPV infection at enrolment. Among 23 girls who reported age at first sex as 1 year younger than their current age, 15 (65.2%) had HPV infection. Of 187 genotype-specific infections at enrolment, 51 (27%) were present at 12 months. Overall, 67% of 97 sexually active participants with results at enrolment and 12 months had a new HPV genotype at follow-up. Among HPV uninfected female subjects at enrolment, the incidence of any HPV infection was 76 per 100 person-years. Conclusions Among young women in Tanzania, HPV is highly prevalent and acquired soon after sexual debut. Early HPV vaccination is highly recommended in this population.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li><li>Tanzanie</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Grand Londres</li></region><settlement><li>Barcelone</li><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Watson Jones, Deborah" sort="Watson Jones, Deborah" uniqKey="Watson Jones D" first="Deborah" last="Watson-Jones">Deborah Watson-Jones</name></region><name sortKey="Andreasen, Aura" sort="Andreasen, Aura" uniqKey="Andreasen A" first="Aura" last="Andreasen">Aura Andreasen</name><name sortKey="Baisley, Kathy" sort="Baisley, Kathy" uniqKey="Baisley K" first="Kathy" last="Baisley">Kathy Baisley</name><name sortKey="Brown, Joelle" sort="Brown, Joelle" uniqKey="Brown J" first="Joelle" last="Brown">Joelle Brown</name><name sortKey="Hayes, Richard J" sort="Hayes, Richard J" uniqKey="Hayes R" first="Richard J" last="Hayes">Richard J. Hayes</name><name sortKey="Kapiga, Saidi" sort="Kapiga, Saidi" uniqKey="Kapiga S" first="Saidi" last="Kapiga">Saidi Kapiga</name><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name></country><country name="Tanzanie"><noRegion><name sortKey="Watson Jones, Deborah" sort="Watson Jones, Deborah" uniqKey="Watson Jones D" first="Deborah" last="Watson-Jones">Deborah Watson-Jones</name></noRegion><name sortKey="Andreasen, Aura" sort="Andreasen, Aura" uniqKey="Andreasen A" first="Aura" last="Andreasen">Aura Andreasen</name><name sortKey="Brown, Joelle" sort="Brown, Joelle" uniqKey="Brown J" first="Joelle" last="Brown">Joelle Brown</name><name sortKey="Changalucha, John" sort="Changalucha, John" uniqKey="Changalucha J" first="John" last="Changalucha">John Changalucha</name><name sortKey="Gumodoka, Balthazar" sort="Gumodoka, Balthazar" uniqKey="Gumodoka B" first="Balthazar" last="Gumodoka">Balthazar Gumodoka</name><name sortKey="Kapiga, Saidi" sort="Kapiga, Saidi" uniqKey="Kapiga S" first="Saidi" last="Kapiga">Saidi Kapiga</name><name sortKey="Kavishe, Bazil" sort="Kavishe, Bazil" uniqKey="Kavishe B" first="Bazil" last="Kavishe">Bazil Kavishe</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name></region><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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